The San Antonio Valley AVA is centered on San Antonio Valley in southern Monterey County, California. The AVA is bordered to the east by the Salinas Valley, and on west by the Santa Lucia Mountains, with its typical warm climate benefiting from the cooling effects of nearby Lake San Antonio and the Pacific Ocean.

The area has one of the longest grape growing traditions in the present day United States, when the Mission San Antonio de Padua was established in 1771 with a small vineyard, in Spanish colonial Las Californias.

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