(shared with Indiana, Kentucky, and West Virginia)

The Ohio River Valley AVA is centered on the Ohio River and surrounding areas. It is the second largest wine appellation of origin in the United States with 16,640,000 acres (26,000 sq mi) (67,300 km2) in portions of the states of Indiana, Kentucky, Ohio and West Virginia. The area is mostly planted with hybrid grapes.

See winery listings for this region